I've only been playing this for 1.5 hours so far :( Wives and daughters take up too much of my time.
Looks like there might be a couple of useful mods to use including one which makes the inventory easier to navigate. I was finding it difficult just to know what was selected so will give that a go. Also one for arachnophobics which turns spiders into bears :?
I'm sure I'll put plenty of hours into it and never finish it like Oblivion, Fallout 3 and FO:NV.
Maybe this would be of some help. http://www.skyrimnexus.com/downloads/file.php?id=1741
I think it allows binding weapons/magic to ,. and [] for left and right hands. I expect it would be more useful for cursor key users rather than wasd.